Strong northeast winds and low humidity are prompting National Weather Service officials to issue a red flag warning in the foothills from Tuesday night to Wednesday night.
"This will be the strongest and most widespread Santa Ana event we have seen so far this season, with Los Angeles and Ventura Counties being the focus of strongest winds," the NWS reported.
Peak winds are expected to reach between 60 to 70 mph overnight in the mountains, about 50 to 60 mph in the valleys and 40 to 50 mph across the Los Angeles coast from Malibu to Hollywood.
"The combination of these strong offshore winds, low humidities and dry fuels will bring a high risk for rapid fire spread across Los Angeles and Ventura Counties should an ignition occur," the NWS reported.
Despite the Santa Ana wind risk, the weather is not expected to be particularly hot: the National Weather Service predicts a high of 80 degrees for Altadena on Wednesday.
The weather is forecast to change quickly after that with showers predicted for Friday, and temperatures in the high 50s over the weekend.
Officials urge locals to call 911 and alert fire crews if a fire is burning.
A fire during these weather conditions could cause widespread damage and threaten lives, according to NWS.